Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
September 8, 2011
Health Canada has issued new restrictions concerning the use of Lupron® (leuprolide acetate). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Medical conditions: People with obstructive uropathy (difficulty urinating because of a block in the urinary tract), seizures, brain tumours, disorders of the blood vessels in the brain, or problems with the central nervous system (brain and spinal cord) should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Men and the heart: There may be an increased risk of heart-related events (e.g., heart attacks, stroke, heart-related death) in men being treated for prostate cancer with GnRH medications. Before you start treatment, tell your doctor if you have diabetes, heart disease, had a previous heart attack or stroke, or have cardiovascular risk factors (e.g., high blood pressure, smoking, or cholesterol). If you have any of these conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Osteoporosis: Leuprolide can cause the bones to lose thickness. People who are at risk for osteoporosis or who are taking other medications that tend to thin bones should be monitored by their doctor while taking this medication.
Starting treatment: During the first few weeks of treatment with leuprolide, you may notice that your signs and symptoms temporarily get worse. This is due to a sudden increase in hormones that will normalize once the right dose for you has been found.
Pregnancy: Leuprolide should not be used during pregnancy. A non-hormonal method of birth control (e.g., condom, diaphragm, IUD) should be used during treatment. If you become pregnant during treatment, notify your doctor as soon as possible.
Breast-feeding: It is not known if leuprolide passes into breast milk. Women should not breast-feed while receiving leuprolide treatment due to risk of harm to the infant.