Smallpox was an infection that was caused by the virus called variola virus. For thousands of years, smallpox created severe illness and caused the death of hundreds of thousands of people. When it was introduced into the Americas from Europe in the 1500s, it killed many of the native populations. As late as the 1800s it was still causing the deaths of thousands when introduced into susceptible populations, such as in Hawaii, by European explorers. Fortunately, this virus was eliminated as a natural cause of disease in 1977 through effective use of vaccination programs. It is the only disease ever to be deliberately removed from the human population.
It is thought, however, that this virus could be reintroduced as an agent of biological warfare. This is because the virus is very contagious (can be spread from person to person) and can cause serious illness, even death, if an individual is not vaccinated within four days of being exposed to the virus. Since antibiotics only work against bacteria, not viruses, they are ineffective against the smallpox virus. There is no known cure.
Prior to 1972, vaccination against smallpox was standard procedure. Since that time, general vaccination against smallpox has not been recommended and therefore has been unavailable to the general population. It is thought that protection gained from the vaccination against smallpox lasts a maximum of 10 years. It is believed that few people in North America currently have protection against this disease. In light of current terrorist activity, the American and Canadian governments have acquired their own emergency supply of smallpox vaccine. These vaccinations would be used to vaccinate any people exposed to the smallpox virus should this become necessary.
The smallpox virus is passed from one person to another through inhalation of air droplets or aerosols. Therefore, it is important to isolate a person diagnosed with smallpox and not have face-to-face contact. The disease is spread most easily during the first week of infection, but the risk of passing the virus to another person lasts until all scabs have fallen off (see "Symptoms and Complications"). Clothing or bedding can also spread the virus.
As a weapon of biological warfare, it is most likely that the smallpox virus would be spread through the ventilation systems of buildings. The viruses would only stay alive for one or two days within the building, but by that time many people may have become infected. Since it takes about 2 weeks for the symptoms of smallpox to develop, it is unlikely that the source of the infection would be discovered in time to do anything about it. Smallpox can be passed between people in any climate, but it spreads most easily in cool, dry winter months. It is believed (and hoped) that the only existing smallpox virus in the world is located at two WHO (World Health Organization)-designated laboratories: the Centers for Disease Control and Prevention in the US and Russia.
Control of fever, prevention of dehydration, good wound care, and antibiotics for any secondary infection caused by bacteria are important measures for the smallpox patient.
If a case of smallpox were diagnosed, that person would be isolated from other people immediately, and all people that had been in contact with that person would be isolated, vaccinated, and watched closely for signs of the disease. Vaccine that is given within 7 days of exposure to the virus may prevent or greatly reduce the symptoms of the disease. The sooner it is given, the more effective it is.
Currently, smallpox vaccine is approved for use only with those people who are at special risk for the disease. Laboratory workers working with the virus are also vaccinated. If an epidemic were to occur, widespread vaccination could take place, with priorities as recommended by the government.
The vaccination against smallpox contains the cowpox (vaccinia) virus, not the smallpox virus. The vaccinia virus, which is related to the smallpox virus, allows the production of antibodies against the smallpox virus by our body’s defense (immune) system. The vaccine is very safe, and was routinely given to the general population before 1972. Certain people are at higher risk for adverse reactions to the vaccine – most reactions are mild, but some are severe. They include people with eczema or other skin conditions, pregnant women, and persons with circumstances that result in weakened immune systems, for instance those with cancers like leukemia and lymphoma and people who have had solid organ transplants.
Medication treatments for smallpox, such as tecovirimat, are available only under exceptional circumstances. These treatments are thought to be effective against other related infections like monkeypox, however they are not currently approved by Health Canada for this use.
All material copyright MediResource Inc. 1996 – 2025. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/condition/getcondition/Smallpox
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