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Pertussis

Pertussis

Facts

Although it’s considered a vaccine-preventable disease, whooping cough (pertussis) certainly hasn’t been eliminated as a public health problem. The incidence of whooping cough has decreased by more than 90% over the last 70 years, but there are still outbreaks. While most other diseases that are vaccinated against in childhood are decreasing in frequency, cases of whooping cough have actually increased since 1990. This is likely due to the lower effectiveness of older vaccines (due to the emergence of new strains of the bacteria that causes the disease), decreased protection from the disease (immunity) in adults and adolescents as the effect of the vaccine wears off, parents opting out of vaccinating their children, and increased reporting of whooping cough by doctors.

Between 1,000 and 3,000 people each year get sick from pertussis. In Canada, 1 to 4 Canadians die each year from whooping cough. In unvaccinated populations, most cases occur in children under 5, especially in babies less than 6 months old. Because the effects of the vaccination wear off, adults are also susceptible to the disease. Those who have had the disease in the past may get it again, but it is usually a mild form which may go unrecognized and undiagnosed.

Causes

Whooping cough is caused by the bacterium Bordetella pertussis. The bacterium is transmitted in tiny droplets that come from the nose and mouth and is spread from person to person. A similar bacterium called Bordetella parapertussis causes a milder version of whooping cough known as parapertussis.

While most cases of pertussis occur in children under 5 years, it may be that the majority of carriers are older. It’s now believed that adults are a major source of infection to infants. It is recommended for all pregnant women to receive a pertussis vaccination in their third trimester of pregnancy. It’s important for people in regular contact with infants to be immunized. Anyone who needs a booster vaccine, should receive it 2 weeks before coming into contact with a newborn baby.

Since many people reach adulthood without having been infected, it’s entirely possible for adults to develop whooping cough. After infants, the people most likely to suffer serious complications from whooping cough are seniors and those with chronic ill health.

The disease takes 1 or 2 weeks to incubate. People become infectious to others by the end of the first week and they typically remain contagious for about 6 weeks. The disease is highly contagious and you will be advised to avoid contact with others while you are still able to infect people.

Treatment and Prevention

Although bacteria cause whooping cough, antibiotics aren’t especially effective in treating it unless they’re given in the first stage. Very often, the disease isn’t recognized until it enters the second stage. Nevertheless, antibiotics such as clarithromycin*, azithromycin, or sulfamethoxazole – trimethoprim are given at this stage to reduce the possibility of complications, even if they don’t cut the duration of the whooping cough itself. Antibiotics may also help to reduce the chances of spreading the infection to others.

Infants with pertussis are often hospitalized, especially those less than 6 months of age. Treatment is designed to minimize symptoms and the damage those symptoms can cause. In the case of heavy vomiting, fluids and electrolytes (e.g., potassium) must be replaced intravenously. In babies, it may be necessary to suck out mucus with a vacuum-like device or to install a nasal breathing tube to help breathing. Extra oxygen may also be necessary. Expectorant and cough-suppressing medications are generally not recommended. Babies with pertussis should be left to sleep as much as possible, since any disturbance or excitement is likely to trigger coughing. In older children, symptoms and risks are much milder, and hospitalization is hardly ever needed.

Most people know there’s a vaccine against whooping cough; however, too many people know about it for the wrong reasons. Antivaccine groups and the media have focused on a one-in-a-million chance of encephalitis (severe brain inflammation) occurring in the hours or days after the vaccination, while not addressing the far larger risk of encephalitis caused by whooping cough in unvaccinated people.

The Canadian pertussis vaccination schedule is as follows: babies are given the DPT (diphtheria – pertussis – tetanus) vaccine at 2 months, 4 months, and 6 months of age to establish basic immunity. They are then given boosters at 18 months, at 4 to 6 years of age, and at 14 to 16 years of age. The first 5 shots (from 2 months to 4 to 6 years) will usually be given in conjunction with polio vaccine and Hemophilus influenzae B or "Hib" vaccine (an anti-pneumonia vaccine), since these have the same schedule as DPT. Additional immunizations are given with some of these first 5 shots, with the exact schedule determined by the province.

To provide continued protection from whooping cough, adults should receive one dose of the pertussis vaccine in combination with the adult diphtheria-tetanus formulation.

*All medications have both common (generic) and brand names. The brand name is what a specific manufacturer calls the product (e.g., Tylenol®). The common name is the medical name for the medication (e.g., acetaminophen). A medication may have many brand names, but only one common name. This article lists medications by their common names. For information on a given medication, check our Drug Information database. For more information on brand names, speak with your doctor or pharmacist.

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