The larynx, also called the voice box or Adam’s apple, is the part of the body that allows humans to produce sounds and speech. The larynx contains the vocal cords (glottis), which vibrate when air passes through. The epiglottis is a small flap of cartilage found at the top of the larynx. The epiglottis protects the airways by keeping food and saliva from going down the trachea (the "windpipe" tube that leads to the lungs).
Cancer of the larynx can occur on the glottis (most laryngeal cancers are there), the supraglottis (the area above the vocal cords that includes the epiglottis), or the subglottis (the area that connects the larynx to the trachea).
Cancer of the larynx affects more men than women, although more women are developing it today due to an increase in smoking in the female population.
Although the exact cause of cancer is unknown, some known risk factors for cancer of the larynx include:
Like most cancers, treatment for laryngeal cancer involves surgery, radiotherapy, chemotherapy, or a combination of treatments. The decision about what type of therapy to use is made according to how advanced the cancer is (i.e., the stage) and exactly where it is located.
Early-stage cancer of the larynx can often be treated with radiation alone. Radiotherapy is the preferred method whenever possible, because it usually doesn’t affect the quality of the voice and side effects are most often temporary. The side effects to radiation can include:
Surgery can involve removing the whole larynx and surrounding tissues or just part of the larynx, depending on how far the cancer has spread.
For very early-stage cancers, a microsurgery may be preferred over radiation therapy. The microsurgery is done without an incision and can be equally effective, completed in a single treatment, and may cause fewer problems with swallowing and speech.
With partial removal (laryngectomy), you will often be able to eat and breathe as you did before the surgery, after healing is complete. You will probably have a temporary tracheostomy while the throat repairs, but the stoma will be allowed to close up and breathing will return to normal. Your voice quality may change but you will be able to speak.
If you need to undergo a total laryngectomy where the voice box is completely removed, you will be left with a tracheostomy in order to breathe. This tracheostomy is permanent.
Finally, chemotherapy may be needed if the cancer has spread. Chemotherapy is also used to "sensitize" the area for radiation in cases of advanced tumours that are still thought to be treatable.
Because chemotherapy circulates throughout the body, more of the body systems are affected by the treatment.
Side effects from chemotherapy include:
Targeted therapies target and inhibit certain molecules which tell cancer cells to grow and divide. Targeted therapy is usually used in combination with radiation therapy in patients that can’t tolerate chemotherapy or with chemotherapy drugs for added efficacy. Just like many other cancer therapies there can often be side effects, which vary depending on which targeted therapy drug is used. The most common side effects include:
Immunotherapy helps strengthen the body’s immune system, and its ability to fight laryngeal cancer. Immunotherapy is usually indicated for recurrent or metastatic cancers. The side effects of immunotherapy can include:
The five-year survival rate for laryngeal cancer that’s detected early is 60% to 90%. Most recurrences of cancer happen within the first 2 or 3 years of treatment. Follow-up procedures usually involve monthly checkups for the first year and then every few months thereafter. Unfortunately, because the very same risk factors that might have caused the first tumour may also have caused other damage, the chances of a second tumour developing (often in the head, neck, or lung) can be as high as 25%.
Many risk factors for cancer of the larynx are known, the most common of these being smoking and heavy alcohol use. Many cases of cancer could be prevented by avoiding these known causes.
Other ways to reduce risk include:
All material copyright MediResource Inc. 1996 – 2025. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/condition/getcondition/Cancer-of-the-Larynx
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