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How does this medication work? What will it do for me?

Busulfan belongs to the group of cancer-fighting medications called antineoplastics, and specifically to the group of antineoplastics called alkylating agents. It is used to treat leukemia (cancer of white blood cells). Busulfan prevents the growth of cancer cells by interfering with the genetic material DNA, which is necessary for the reproduction of cells.

It can also be used in combination with other chemotherapy regimens prior to stem cell transplants for certain leukemias, lymphomas (cancer of the lymph cells), multiple myeloma (cancer of the plasma cells), and other genetic conditions that have not responded to other therapies or are very aggressive.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The recommended dose and dosing schedule of busulfan varies according to the specific type of cancer being treated, the response to therapy, other medications or treatments being used, and is also based on body size. Busulfan is either taken as an oral tablet daily or injected into a vein through a site on the skin that has been specially prepared for this purpose.

The dose should be taken at the same time each day to have the best effect. Your doctor may want you to drink extra fluids while taking this medication to prevent kidney problems.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor.

This medication may cause nausea, vomiting, and loss of appetite, but it is important that you continue to use the medication. Do not stop taking it without talking with your doctor. If you vomit shortly after taking a dose of this medication, call your doctor for instructions on whether to skip that dose or to take another dose.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

As well as interfering with the genetic material DNA of cancer cells, busulfan can interfere with some of your normal cells. This can cause a number of side effects such as hair loss and mouth sores. Keep track of any side effects and report them to your doctor, as suggested in the section "What side effects are possible with this medication?"

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

Each 10 mL vial contains 60 mg busulfan at a concentration of 6 mg/mL for intravenous use. Nonmedicinal ingredients: dimethylacetaminde and polyethylene glycol 400, NF, in quantities of 3.333 mL and 6.667 mL, respectively.

Who should NOT take this medication?

Do not take this medication if you:

  • are allergic to busulfan or any ingredients of this medication
  • have a low platelet count
  • have a low white blood cell count
  • have not responded well to busulfan in the past

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • confusion
  • constipation
  • darkening of skin
  • dry mouth
  • headache
  • itching
  • loss of appetite
  • missed or irregular menstrual periods
  • nausea and vomiting
  • nose bleeding
  • overall fatigue or muscle pain
  • rash
  • sleeping problems
  • sore throat or cough
  • stuffy, runny nose or sneezing
  • sudden weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abrupt weakness
  • black, tarry stools or blood in the urine or stools
  • chest pain
  • cough or hoarseness
  • dizziness
  • fast or irregular breathing
  • fever or chills
  • joint pain
  • lightheadedness
  • lower back or side pain
  • painful or difficult urination
  • persistent congestion
  • pinpoint red spots on the skin
  • puffiness or swelling around the face
  • rapid heartbeat
  • shortness of breath
  • sudden, severe decrease in blood pressure
  • sweating
  • swelling of the fingers, hands, arms, lower legs, or feet
  • tingling in the lower legs, hands, or feet
  • unusual bleeding or bruising
  • yellowing of the skin and eyes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • blurred vision
  • difficulty swallowing
  • heartburn
  • severe upper abdominal and back pain
  • vomiting blood

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Blood clotting: This medication can reduce the number of platelet cells in the blood. Platelets help the blood to clot, and a shortage could make you bleed more easily.

Tell your doctor about any signs that your blood is not clotting as quickly as usual. Symptoms include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding.

Fertility: Sterility may occur with the use of busulfan.

Gout: This medication may cause high levels of uric acid in the blood, making gout more likely to occur.

Infection: As well as killing cancer cells, this medication can reduce the number of cells that fight infection in the body (white blood cells). Avoid contact with people who have contagious infections and tell your doctor if you begin to notice the signs of an infection such as fever or chills.

Liver: This medication can impair liver function. Your doctor will monitor you for this with blood tests.

Lung disease: This medication may rarely cause a form of lung disease. Contact your doctor immediately if you develop a persistent cough, shortness of breath, or fever. Routine breathing tests may be required.

Seizures: High doses of busulfan can increase the risk of seizures, along with anyone who has a history of seizures, has experienced head trauma, or is receiving other medications which can cause seizures.

Pregnancy: There is a possibility of birth defects if either the father or mother is taking busulfan at the time of conception, or if it is taken during pregnancy. Effective birth control should be practiced while using this medication. If you become pregnant while taking this medication, talk to your doctor immediately.

Breast-feeding: It is not known if busulfan passes into breast milk. Women should not breast-feed while receiving busulfan treatment due to risk of potential harm to the infant.

What other drugs could interact with this medication?

There may be an interaction between busulfan and any of the following:

  • azathioprine
  • itraconazole
  • methotrexate
  • other cancer medications or medications that suppress the immune system
  • phenytoin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2017. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source:

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