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Botulin Toxin

Clostridium Botulinum Toxin, Botulin Toxin

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Facts

Most people know that botulism is dangerous, but many are confused about whether it’s an infection or a case of poisoning. In fact, it can be both. Clostridium botulinum is a worldwide bacterium that inhabits rivers, soil, and the guts of mammals, fish, and shellfish. It’s not an organism that normally makes its living by attacking humans. We most often encounter C. botulinum by accident.

C. botulinum secretes a neurotoxin (nerve poison) that can weaken or paralyze muscles and can even cause death. This is botulin toxin, one of the most dangerous substances known. Botulism is the condition of having been poisoned with C. botulinum toxin.

Causes

Botulism is rare, but there are still cases every year.
There are 6 ways to get botulism:

  • Foodborne botulism occurs when food contaminated with the toxin is eaten. The bacteria are dead or gone by the time you eat the food, but the toxin remains. Most foodborne botulism is attributed to home-canned foods, but outbreaks occasionally occur in commercially-prepared foods.
  • Infant botulism occurs when infants under 12 months of age eat bacterial spores rather than the toxins. Spores of C. botulinum then grow in the infant’s intestines, where they produce toxins. Honey can contain spores of C. botulinum and is associated with infant botulism and should not be given to children under 12 months old. Infant botulism is rare.
  • Adult intestinal colonization botulism occurs when C. botulinum spores are ingested. The spores grow and eventually produce toxins in the digestive system. People with altered gastrointestinal systems and local microbes (due to surgery, presence of inflammatory bowel disease, or exposure to antibiotics) are most often affected.
  • Wound botulism occurs when live bacteria infect an open cut and the toxin is carried through the body by the blood.
  • Bioterrorism-associated botulism is a possible terrorist threat. It would be delivered by aerosol or foodborne means.
  • Iatrogenic botulism caused by cosmetic use of botulin toxin occurs when people receive botulinum toxin injections (e.g., Botox®) for a variety of health reasons or cosmetic purposes. If injected improperly or at the wrong dose, this could cause botulism.

Rarely, toxins can be inhaled or absorbed through the eyes.

Botulism can cause death due to paralysis of muscles used in breathing. However, advancements in supportive care have greatly reduced the death rate, and now less than 10% of people who get botulism die from the condition.

Treatment and Prevention

Supportive care is provided to anyone with botulism. This may include hospitalization, use of a ventilator to help with breathing, and nursing care. Recovery can take many weeks as paralysis slowly improves.

While there is a botulism antitoxin and immune globin therapy, they are not approved for sale in Canada and are currently only available through Health Canada’s Special Access Program.

The antitoxin works by neutralizing botulin. However, the antitoxin needs to be administered as soon as possible after diagnosis. The medication can’t repair nerve endings already damaged. This means that while you may survive, you will be temporarily left in the state you were in at the time the medication was administered. That may mean paralysis, sometimes to the point of being unable to talk or even swallow.

The good news is that you’ll recover, because new nerves can grow to replace those that were killed. However, this is a slow recovery process and it may take weeks or months, even up to a year, for this to occur.
For wound botulism, antibiotics are given in addition to supportive care.

Preventing botulism is usually possible. However, if you prepare and store a lot of your own food, you may be creating unnecessary risk. The C. botulinum bacterium is anaerobic, meaning it likes airless environments. This is why you can get foodborne botulism out of a can. Very few cases of botulism arise from commercially canned food. Most occur when individuals can their own products.

Botulin toxin has been found in North America in these foods:

  • asparagus
  • baked potatoes
  • beets
  • canned corn
  • chicken, chicken livers, and liver paté
  • garlic-in-oil dressing
  • green beans
  • ham
  • lobster
  • luncheon meats
  • mushrooms
  • peppers
  • ripe olives
  • sausage
  • smoked and salted fish
  • soups
  • spinach
  • stuffed eggplant
  • tuna fish

Only highly acidic foods are safe from C. botulinum. Freezing will shut down toxin production, but a fridge isn’t cold enough. The following food handling procedures can help you to prevent foodborne botulism:

  • Preserved food should be heated to a temperature above 100°C (212°F) for at least 10 minutes during the canning process.
  • Cook food at 79.9°C (176°F) for at least 30 minutes. This usually destroys toxins.
  • Do not eat or store cooked foods that have been at room temperature for 2 hours or more.
  • Do not eat foil-wrapped baked potatoes that have been left at room temperature, and do not store chopped garlic or onions in oil at room temperature.
  • If eating home-canned food, boil it first with frequent stirring for 10 minutes.
  • Do not feed honey to infants less than 12 months old.

All material copyright MediResource Inc. 1996 – 2026. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/condition/getcondition/Botulism

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