There is not enough evidence to determine if yohimbe is effective for any health condition. Yohimbe has been associated with high blood pressure, increased heart rate, headache, anxiety, dizziness, nausea, vomiting, tremors, and sleeplessness. Yohimbe can be dangerous if taken in large doses or for long periods of time.
People should not combine yohimbe with monoamine oxidase (MAO) inhibitors, as their effect may be greater when combined. Yohimbe should be used with caution when taken with medicines for high blood pressure, tricyclic antidepressants, antiplatelets, anticoagulants, or phenothiazines (a group of medicines used mostly for mental health conditions such as schizophrenia). Yohimbe can also interaction with stimulants, naloxone, and certain drugs metabolized by the liver (e.g., codeine, donepezil).
People with certain diseases should not use yohimbe. These include:
- bleeding conditions
- heart disease
- high or low blood pressure
- kidney problems
- liver disease
- psychiatric conditions
Stop taking yohimbe at least 2 weeks before elective surgery to avoid excessive bleeding.
Women who are pregnant or breast-feeding and children should not take yohimbe.
Before taking any new medications, including natural health products, speak to your physician, pharmacist, or other health care provider. Tell your health care provider about any natural health products you may be taking.