Vitamin B6 is likely safe when taken in recommended daily amounts. When taken in large amounts over a long period of time, vitamin B6 can cause nausea, vomiting, heartburn, headache, tiredness, abnormal heart rhythms, decreased muscle tone, movement incoordination, painful skin patches, drowsiness, sedation, sensitivity to the sun, and a burning, prickling, or tingling sensation in the arms and legs.
Vitamin B6 supplementation is safe for pregnant and breast-feeding women when taken in daily recommended doses under the supervision of a health care professional.
Vitamin B6 can interact with certain medications, including levodopa (used in Parkinson's disease), estrogen, amiodarone, cycloserine, theophyllin, phenobarbital, and anti-seizure medications (e.g. phenytoin). Consult your health care provider if you have any concerns.
Before taking any new medications, including natural health products, speak to your physician, pharmacist, or other health care provider. Tell your health care provider about any natural health products you may be taking.