Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
September 8, 2011
Health Canada has issued new restrictions concerning the use of Zoladex LA® (goserelin [long-acting]). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Heart problems: People with heart disease or other heart problems such as heart failure or an abnormal heart rhythm should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Men and the heart: There may be an increased risk of heart-related events (e.g., heart attacks, stroke, heart-related death) in men being treated for prostate cancer with GnRH medications. Before you start treatment, tell your doctor if you have diabetes, heart disease, had a previous heart attack or stroke, or have cardiovascular risk factors (e.g., high blood pressure, smoking, or cholesterol). If you have any of these conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Osteoporosis: Goserelin can cause bones to lose thickness. People at an increased risk for osteoporosis or who are taking medications that reduce bone thickness (e.g., prednisone or antiseizure medications), should discuss the risks and benefits of using goserelin with their doctor before starting treatment. Your doctor should monitor your bone thickness while you are taking this medication. Some people taking goserelin may be prescribed medications to reduce bone loss.
Pituitary tumour: Although very rare, pituitary gland tumours may develop, bleed, or collapse with goserelin treatment. If you experience severe headaches, vomiting, loss of eyesight or unconsciousness, get immediate medical attention.
Short-term worsening of medical condition: For some people, their medical condition may temporarily worsen during the first month of treatment with goserelin. If your medical condition appears to worsen, contact your doctor.
Spine problems: When people with cancer that has spread to their spine receive goserelin, spinal cord compression can occur. If you develop severe pain, numbness or weakness of the arms or legs, or difficulty urinating, contact your doctor immediately.
Pregnancy: Goserelin should not be used during pregnancy. A nonhormonal method of birth control (e.g., condom, diaphragm) should be used during treatment. If you become pregnant while using this medication, stop receiving goserelin and contact your doctor.
Breast-feeding: It is not known if goserelin passes into breast milk. Women should not breast-feed while receiving goserelin treatment due to risk of harm to the breast-feeding infant.
Children: The safety and effectiveness of using the medication have not been established for children.