Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood clots: This medication appears to increase the risk of developing blood clots. These blood clots may form anywhere in the body, but are more noticeable when they occur in the large muscles, lung, brain (stroke), or heart (heart attack). If you experience pain in the chest or leg, unexplained shortness of breath, fast and irregular heartbeat, severe headache, blurred vision, or slurred speech, get immediate medical attention.
Eye problems: There have been rare reports of retinal detachment and retinal vein occlusion (blockage of the vein draining the eye) in people taking trametinib. If you notice any changes in your vision such as coloured dots, halos, or blurred vision contact your doctor immediately.
Heart problems: Trametinib may cause the heart to become less effective in pumping blood out into the body. If you have a history of heart disease or are at risk of developing heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience signs of decreased heart function, like a change in heartbeat or pulse, chest pain, difficulty breathing, unusual tiredness or swelling in the legs, feet or hands, contact your doctor as soon as possible.
High blood pressure: Trametinib may increase your blood pressure. Your doctor will monitor your blood pressure while you are taking this medication.
Lungs: This medication is known to serious lung and breathing problems. The resulting damage to the lungs can be fatal. If you experience any new or worsening cough or shortness of breath while using this medication, contact your doctor immediately. Your doctor may order a chest X-ray before you start using this medication to use as a baseline should you develop breathing problems.
Skin problems: This medication can cause additional skin problems such as rash, skin ulcers that may become infected, and other skin redness and irritation. These reactions can lead to serious problems. Let your doctor know as soon as possible if you develop any skin reactions while you are taking trametinib.
Vision changes: This medication may cause changes to the sharpness of your vision and possibly cause vision loss. Vision loss can occur slowly or suddenly. People with high blood pressure, diabetes, high blood cholesterol, or glaucoma are at a higher risk of vision loss. Your doctor may order an eye exam before you start taking tremetanib. If you notice any change in your vision such as colour dots, a blurred outline around objects (halo), or blurred vision while you are taking trametinib, contact your doctor immediately.
Pregnancy: This medication may cause harm to an unborn child and should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately. Women of childbearing age who are taking trametinib should use an effective method of birth control such as condoms during treatment and for 4 weeks after stopping the medication.
Breast-feeding: It is not known if trametinib passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.