Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These
factors may affect how you should use this medication.
Drowsiness and dizziness: This medication can cause drowsiness and dizziness that may affect your ability to drive or operate machinery safely. If this medication affects you in this way, do not perform these tasks.
Fluid and electrolyte balance: NSAIDs such as ketoprofen can cause fluid retention and edema (swelling). This can lead to high blood pressure or worsening of heart failure. If you have heart failure or high blood pressure, discuss with your doctor
how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Infection: This medication may mask the signs of infection (e.g., fever). If you notice other symptoms of infection (e.g., painful or frequent urination, productive cough) contact your doctor.
Kidney function: Long-term use of ketoprofen may lead to a higher risk of reduced kidney function. You have a higher risk of developing kidney problems if you are a senior, take diuretics (water pills), or already have kidney disease, liver disease,
or heart failure. Your doctor will monitor your kidney function with blood tests if you take this medication for a long period of time.
Liver problems: This medication may affect your liver function or cause liver problems. Your doctor will monitor your liver function with blood tests if you take this medication for a long period of time.
If you experience symptoms of liver problems
(e.g., nausea, vomiting, feeling tired, yellowing of the skin or eyes) contact your doctor immediately. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing
and effectiveness of this medication, and whether any special monitoring is needed.
Ulcers or bleeding in the stomach or intestines: Ketoprofen can cause stomach ulcers, perforations (holes), and bleeding from the stomach. These complications can occur at any time without warning, and are sometimes severe enough to require immediate
medical attention. The risk of ulcers and bleeding increases if you are taking higher doses of ketoprofen for longer periods of time.
Other factors that increase the risk of these complications include drinking excessive amounts of alcohol, increased age, smoking, poor health, H pylori infection, and taking certain medications (e.g., warfarin, ASA, clopidogrel, prednisone, citalopram,
fluoxetine, paroxetine, sertraline).
If you currently have ulcers in the stomach or intestines that are bleeding, or have an inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), you should not take this medication. If you have a history of these conditions, discuss with your
doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Stop taking the medication and get immediate medical attention if you experience symptoms or signs of stomach ulcers or bleeding in the stomach (black, tarry stools; blood in stools; stomach pain; vomiting blood or material that looks like coffee grounds). These reactions
can occur at any time during treatment without warning.
Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication should not be used by women who are breast-feeding
Children: The safety and effectiveness of using this medication have not been established for children under 12 years of age.
Seniors: If you are a senior, your doctor may use lower doses of this medication than usually recommended.