Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergic reactions: In rare cases, some people may develop a severe allergic reaction to this medication. These reactions may not occur with the first infusion of the medication, and may happen with future doses of vedolizumab. Your health care provider will monitor you while you are receiving vedolizumab by infusion. Signs of an allergic reaction include a severe rash, hives, swollen face or throat, difficulty breathing, lightheadedness, or dizziness. If any of these occur, contact your doctor immediately.
Infections: This medication may increase the risk of developing an infection, including serious infections such as sepsis, pneumonia, and tuberculosis. Before starting vedolizumab treatment, your doctor may test to see if you have tuberculosis. If you notice signs of an infection such as fever, chills, pain, swelling, coughing or pus, contact your doctor as soon as possible. This medication should also not be started while you have an active infection.
Progressive multifocal leukoencephalopathy (PML): Although there have not been reports of PML after using vedolizumab, it has been reported with other medications in the same family. PML is a rare disorder that causes nerve damage in the brain. If you experience memory loss, vision loss, trouble thinking, or difficulty walking, contact your doctor immediately.
Vaccines: Live vaccines (e.g., BCG, yellow fever) are not recommended for people taking this medication. Talk to your doctor if you need any vaccinations while taking this medication.
Pregnancy: This medication should not be used during pregnancy. If you are of childbearing age, effective birth control should be used while you are being treated with vedolizumab and for at least 18 weeks after your final treatment. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if vedolizumab passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.